AI for Healthcare

3D intraoral scans (IOS) are increasingly adopted in routine dentistry due to abundant geometric evidence, and unified multi-disease diagnosis is desirable for clinical documentation and communication. While recent works introduce dental vision-language models (VLMs) to enable unified diagnosis and report generation on 2D images or multi-view images rendered from IOS, they do not fully leverage...

Generative models are increasingly used to augment medical imaging datasets for fairer AI. Yet a key assumption often goes unexamined: that generators themselves produce equally high-quality images across demographic groups. Models trained on imbalanced data can inherit these imbalances, yielding degraded synthesis quality for rare subgroups and struggling with demographic intersections absent...

Artificial intelligence (AI)-enabled digital interventions, including Generative AI (GenAI) and Human-Centered AI (HCAI), are increasingly used to expand access to digital psychiatry and mental health care. This PRISMA-ScR scoping review maps the landscape of AI-driven mental health (mHealth) technologies across five critical phases: pre-treatment (screening/triage), treatment (therapeutic...

Deep learning has achieved remarkable success in medical image analysis, yet its performance remains highly sensitive to the heterogeneity of clinical data. Differences in imaging hardware, staining protocols, and acquisition conditions produce substantial domain shifts that degrade model generalization across institutions. Here we present a physics-based data preprocessing framework based on the...

Causal discovery in health data faces evaluation challenges when ground truth is unknown. We address this by collaborating with experts to construct proxy ground-truth graphs, establishing benchmarks for synthetic Alzheimer's disease and heart failure clinical records data. We evaluate the Peter-Clark, Greedy Equivalence Search, and Fast Causal Inference algorithms on structural recovery and...

This dissertation investigates privacy-preserving federated learning for Alzheimer's disease classification using three-dimensional MRI data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Existing methodologies often suffer from unrealistic data partitioning, inadequate privacy guarantees, and insufficient benchmarking, limiting their practical deployment in healthcare. To...

Disentangling pathological changes from physiological aging in 3D medical shapes is crucial for developing interpretable biomarkers and patient stratification. However, this separation is challenging when diagnosis labels are limited or unavailable, since disease and aging often produce overlapping effects on shape changes, obscuring clinically relevant shape patterns. To address this challenge,...

Machine learning models deployed in critical care settings exhibit demographic biases, particularly gender disparities, that undermine clinical trust and equitable treatment. This paper introduces FairMed-XGB, a novel framework that systematically detects and mitigates gender-based prediction bias while preserving model performance and transparency. The framework integrates a fairness-aware loss...

This research paper outlines the development and implementation of a novel Clinical Decision Support System (CDSS) that integrates AI predictive modeling with medical knowledge bases. It utilizes the quantifiable information elements in lab results for inferring likely diagnoses a patient might have. Subsequently, suggesting investigations to confirm the likely diagnoses -- an assistive tool for...

We propose a deep learning framework for COVID-19 detection and disease classification from chest CT scans that integrates both 2.5D and 3D representations to capture complementary slice-level and volumetric information. The 2.5D branch processes multi-view CT slices (axial, coronal, sagittal) using a DINOv3 vision transformer to extract robust visual features, while the 3D branch employs a...

Early identification of patients at risk for clinical deterioration in the intensive care unit (ICU) remains a critical challenge. Delayed recognition of impending adverse events, including mortality, vasopressor initiation, and mechanical ventilation, contributes to preventable morbidity and mortality. We present a multimodal deep learning approach that combines structured time-series data...

Contrastive learning (CL) has become a powerful approach for learning representations from unlabeled images. However, existing CL methods focus predominantly on visual appearance features while neglecting topological characteristics (e.g., connectivity patterns, boundary configurations, cavity formations) that provide valuable cues for medical image analysis. To address this limitation, we...

Vision language models (VLMs) have shown significant promise in visual grounding for images as well as videos. In medical imaging research, VLMs represent a bridge between object detection and segmentation, and report understanding and generation. However, spatial grounding of anatomical structures in the three-dimensional space of medical images poses many unique challenges. In this study, we...

Accurate 3D anatomical segmentation is essential for clinical diagnosis and surgical planning. However, automated models frequently generate suboptimal shape predictions due to factors such as limited and imbalanced training data, inadequate labeling quality, and distribution shifts between training and deployment settings. A natural solution is to iteratively refine the predicted shape based on...

While Multimodal Large Language Models (MLLMs) show promising performance in automated electrocardiogram interpretation, it remains unclear whether they genuinely perform actual step-by-step reasoning or just rely on superficial visual cues. To investigate this, we introduce \textbf{ECG-Reasoning-Benchmark}, a novel multi-turn evaluation framework comprising over 6,400 samples to systematically...

Generalist multimodal large language models (MLLMs) have achieved impressive performance across a wide range of vision-language tasks. However, their performance on medical tasks, particularly in zero-shot settings where generalization is critical, remains suboptimal. A key research gap is the limited understanding of why medical MLLMs underperform in medical image interpretation. In this work,...

Closed-source large language models (LLMs), such as ChatGPT and Gemini, are increasingly consulted for medical advice, yet their explanations may appear plausible while failing to reflect the model's underlying reasoning process. This gap poses serious risks as patients and clinicians may trust coherent but misleading explanations. We conduct a systematic black-box evaluation of faithfulness...

Chain-of-thought (CoT) reasoning has advanced medical visual question answering (VQA), yet most existing CoT rationales are free-form and fail to capture the structured reasoning process clinicians actually follow. This work asks: Can traceable, multi-step reasoning supervision improve reasoning accuracy and the interpretability of Medical VQA? To this end, we introduce Step-CoT, a large-scale...

Accurate extraction of Alzheimer's Disease and Related Dementias (ADRD) phenotypes from electronic health records (EHR) is critical for early-stage detection and disease staging. However, this information is usually embedded in unstructured textual data rather than tabular data, making it difficult to be extracted accurately. We therefore propose LLM-MINE, a Large Language Model-based...

Developing predictive models that perform reliably across diverse patient populations and heterogeneous environments is a core aim of medical research. However, generalization is only possible if the learned model is robust to statistical differences between data used for training and data seen at the time and place of deployment. Domain generalization methods provide strategies to address data...

Open-world embodied agents must solve long-horizon tasks where the main bottleneck is not single-step planning quality but how interaction experience is organized and evolved. To this end, we present Steve-Evolving, a non-parametric self-evolving framework that tightly couples fine-grained execution diagnosis with dual-track knowledge distillation in a closed loop. The method follows three...

Medical image segmentation (MIS) is a fundamental component of computer-assisted diagnosis and clinical decision support systems. Over the past decade, numerous architectures specifically tailored to medical imaging have emerged to address domain-specific challenges such as low contrast, small anatomical structures, and limited annotated data. In parallel, rapid progress in computer vision has...

Statistically consistent methods based on the noise transition matrix ($T$) offer a theoretically grounded solution to Learning with Noisy Labels (LNL), with guarantees of convergence to the optimal clean-data classifier. In practice, however, these methods are often outperformed by empirical approaches such as sample selection, and this gap is usually attributed to the difficulty of accurately...

We present a fairness-aware framework for multi-class lung disease diagnosis from chest CT volumes, developed for the Fair Disease Diagnosis Challenge at the PHAROS-AIF-MIH Workshop (CVPR 2026). The challenge requires classifying CT scans into four categories -- Healthy, COVID-19, Adenocarcinoma, and Squamous Cell Carcinoma -- with performance measured as the average of per-gender macro F1...

While Large Language Models (LLMs) achieve expert-level performance on standard medical benchmarks through single-hop factual recall, they severely struggle with the complex, multi-hop diagnostic reasoning required in real-world clinical settings. A primary obstacle is "shortcut learning", where models exploit highly connected, generic hub nodes (e.g., "inflammation") in...

Large language model (LLM) agents extend conventional generative models by integrating reasoning, tool invocation, and persistent memory. Recent studies suggest that such agents may significantly improve clinical workflows by automating documentation, coordinating care processes, and assisting medical decision making. However, despite rapid progress, deploying autonomous agents in healthcare...

Depression is a severe mental disorder, and reliable identification plays a critical role in early intervention and treatment. Multimodal depression detection aims to improve diagnostic performance by jointly modeling complementary information from multiple modalities. Recently, numerous multimodal learning approaches have been proposed for depression analysis; however, these methods suffer from...

While specialized Medical Vision-Language Models (VLMs) have achieved remarkable success in interpreting 2D and 3D medical modalities, their deployment for 3D volumetric data remains constrained by significant computational inefficiencies. Current architectures typically suffer from massive anatomical redundancy due to the direct concatenation of consecutive 2D slices and lack the flexibility to...

In medical image segmentation tasks, the domain gap caused by the difference in data collection between training and testing data seriously hinders the deployment of pre-trained models in clinical practice. Continual Test-Time Adaptation (CTTA) aims to enable pre-trained models to adapt to continuously changing unlabeled domains, providing an effective approach to solving this problem. However,...

Clinical diagnosis is a complex cognitive process, grounded in dynamic cue acquisition and continuous expertise accumulation. Yet most current artificial intelligence (AI) systems are misaligned with this reality, treating diagnosis as single-pass retrospective prediction while lacking auditable mechanisms for governed improvement. We developed DxEvolve, a self-evolving diagnostic agent that...

Unmanned aerial vehicles (UAVs) are increasingly used to support time-critical medical supply delivery, providing rapid and flexible logistics during emergencies and resource shortages. However, effective deployment of UAV fleets requires coordination mechanisms capable of prioritizing medical requests, allocating limited aerial resources, and adapting delivery schedules under uncertain...

Brief Hospital Course (BHC) narratives must be clinically useful yet faithful to fragmented EHR evidence. LLM-based clinical summarizers still introduce unsupported statements, and alignment can encourage omissions ("say-less" degeneration). We introduce VERI-DPO, which uses claim verification to mine preferences and distill them into the summarizer with Direct Preference Optimization...

Multimodal neuroimaging provides complementary insights for Alzheimer's disease diagnosis, yet clinical datasets frequently suffer from missing modalities. We propose ACADiff, a framework that synthesizes missing brain imaging modalities through adaptive clinical-aware diffusion. ACADiff learns mappings between incomplete multimodal observations and target modalities by progressively...

While Multi-Agent Systems (MAS) show potential for complex clinical decision support, the field remains hindered by architectural fragmentation and the lack of standardized multimodal integration. Current medical MAS research suffers from non-uniform data ingestion pipelines, inconsistent visual-reasoning evaluation, and a lack of cross-specialty benchmarking. To address these challenges, we...

Brain network analysis based on functional Magnetic Resonance Imaging (fMRI) is pivotal for diagnosing brain disorders. Existing approaches typically rely on predefined functional sub-networks to construct sub-network associations. However, we identified many cross-network interaction patterns with high Pearson correlations that this strict, prior-based organization fails to capture. To overcome...

Dataset condensation (DC) learns a compact synthetic dataset that enables models to match the performance of full-data training, prioritising utility over distributional fidelity. While typically explored for computational efficiency, DC also holds promise for healthcare data democratisation, especially when paired with differential privacy, allowing synthetic data to serve as a safe alternative...

Vision-language pretraining has driven significant progress in medical image analysis. However, current methods typically supervise visual encoders using one-hot labels or free-form text, neither of which effectively captures the complex semantic relationships among clinical findings. In this study, we introduce VIVID-Med, a novel framework that leverages a frozen large language model (LLM) as a...

Background: Remote patient monitoring (RPM) generates vast data, yet landmark trials (Tele-HF, BEAT-HF) failed because data volume overwhelmed clinical staff. While TIM-HF2 showed 24/7 physician-led monitoring reduces mortality by 30%, this model remains prohibitively expensive and unscalable. Methods: We developed Sentinel, an autonomous AI agent using Model Context Protocol (MCP) for...

Multi-modal large language models (MM-LLMs) have shown strong performance in medical image understanding and clinical reasoning. Recent medical agent systems extend them with tool use and multi-agent collaboration, enabling complex decision-making. However, these systems rely almost entirely on frontier models (e.g., GPT), whose API-based deployment incurs high cost, high latency, and privacy...

Recent advances in medical large language models have explored Test-Time Reinforcement Learning (TTRL) to enhance reasoning. However, standard TTRL often relies on majority voting (MV) as a heuristic supervision signal, which can be unreliable in complex medical scenarios where the most frequent reasoning path is not necessarily the clinically correct one. In this work, we propose a novel and...

Pathology underpins modern diagnosis and cancer care, yet its most valuable asset, the accumulated experience encoded in millions of narrative reports, remains largely inaccessible. Although institutions are rapidly digitizing pathology workflows, storing data without effective mechanisms for retrieval and reasoning risks transforming archives into a passive data repository, where institutional...

Concept Bottleneck Models (CBMs) are a prominent framework for interpretable AI that map learned visual features to a set of meaningful concepts for task-specific downstream predictions. Their sequential structure enhances transparency by connecting model predictions to the underlying concepts that support them. In medical imaging, where transparency is essential, CBMs offer an appealing...

We report the first in-air irradiations of biological samples with kHz laser-driven electrons with beam energy 20 MeV, high-energy tail extending to 40 MeV, and average dose rate up to 30 Gy/min. An in-house procedure has been developed to characterize and deliver on-demand (i.e. pre-agreed date and time) the target electron beam energy, dose and dose uniformity. We present a tolerance analysis...

Large language model (LLM)-based AI systems have shown promise for patient-facing diagnostic and management conversations in simulated settings. Translating these systems into clinical practice requires assessment in real-world workflows with rigorous safety oversight. We report a prospective, single-arm feasibility study of an LLM-based conversational AI, the Articulate Medical Intelligence...

Large language models (LLMs) show significant potential for clinical decision support (CDS), yet their black-box nature -- characterized by untraceable reasoning and probabilistic hallucinations -- poses severe challenges in acupuncture, a field demanding rigorous interpretability and safety. To address this, we propose CORE-Acu, a neuro-symbolic framework for acupuncture clinical decision...

Accurate and interpretable mortality risk prediction in intensive care units (ICUs) remains a critical challenge due to the irregular temporal structure of electronic health records (EHRs), the complexity of longitudinal disease trajectories, and the lack of clinically grounded explanations in many data-driven models. To address these challenges, we propose \textit{TA-RNN-Medical-Hybrid}, a...

Advancements in data-driven machine learning have emerged as a pivotal element in supporting automotive software systems (ASSs) engineering across various levels of the V-development process. Duringsystemverificationandvalidation,theintegrationofanintelligent fault detection anddiagnosis (FDD) model with test recordings analysis process serves as a powerful tool for efficiency ensuring functional...

Forecasting physiological signals can support proactive monitoring and timely clinical intervention by anticipating critical changes in patient status. In this work, we address multivariate multi-horizon forecasting of physiological time series by jointly predicting heart rate, oxygen saturation, pulse rate, and respiratory rate at forecasting horizons of 15, 30, and 60 seconds. We propose a...

Fault diagnosis is critical for the safe operation of industrial systems. Conventional diagnosis models typically produce abstract outputs such as anomaly scores or fault categories, failing to answer critical operational questions like "Why" or "How to repair". While large language models (LLMs) offer strong generalization and reasoning abilities, their training on discrete...

Large healthcare institutions typically operate multiple business intelligence (BI) teams segmented by domain, including clinical performance, fundraising, operations, and compliance. Due to HIPAA, FERPA, and IRB restrictions, these teams face challenges in sharing patient-level data needed for analytics. To mitigate this, A metric aggregation table is proposed, which is a precomputed,...